Chemical and Enzymatic Process for the Dentration of Diethyleneglycol Dinitrate, Nitroglycern and Other Nitrate Esters
نویسنده
چکیده
Primary Examiner-Ronald W. Griffin Assistant Examiner-Pamela S. Webber Attorney, Agent, or Firm-Robert P. Gibson; Edward Goldberg; Edward F. Costigan 57 ABSTRACT A process for denitrating the dinitrate ester of diethyl eneglycol is disclosed which comprises introducing the dinitrate ester of diethyleneglycol into an aqueous phos phate buffer containing the tripeptide reduced glutathi one and the enzyme glutathione S-transferase.
منابع مشابه
Reaction of organic nitrate esters and S-nitrosothiols with reduced flavins: a possible mechanism of bioactivation.
Organic nitrate esters, such as glyceryl trinitrate and isosorbide dinitrate, are a class of compounds used to treat a variety of vascular ailments. Their effectiveness relies on their ability to be bioactivated to nitric oxide (NO) which, in turn, relaxes vascular smooth muscle. Although there have been many biological studies that indicate that NO can be formed from organic nitrate esters in ...
متن کاملOld yellow enzyme: reduction of nitrate esters, glycerin trinitrate, and propylene 1,2-dinitrate.
The reaction of the old yellow enzyme and reduced flavins with organic nitrate esters has been studied. Reduced flavins have been found to react readily with glycerin trinitrate (GTN ) (nitroglycerin) and propylene dinitrate, with rate constants at pH 7.0, 25 degrees C of 145 M(-1)s(-1) and 5.8 M(-1)s(-1), respectively. With GTN, the secondary nitrate was removed reductively 6 times faster than...
متن کاملSynthesis and Characterization of Waterglass-Based Silica Aerogel Under Heat Treatment for Adsorption of Nitrate from Water: Batch and Column Studies
In this work, hydrophobic silica aerogels were synthesized using sol-gel method and drying at ambient pressure. The surface morphology, pore size, and the presence of functional groups on the surface of the nanoparticles were analyzed using FE-SEM, TGA, FT-IR, and EDX, respectively. After calcination at 500 °C, the hydrophilic property of the adsorbents was evaluated by water contact angle meas...
متن کاملPotassium carbonate: a highly efficient catalyst for the acylation of alcohols, phenols and thiols under mild conditions
A general, mild and efficient protocol has been developed for the synthesis of esters and thioesters. The process has been taking place using tetra n-butylammonium iodide (TBAI) as a phase-transfer catalyst and in the presence of potassium carbonate (K2CO3). A wide range of esters and thioesters was prepared in high yields and suitable times by the treatment of alcohols, phenols and thiols with...
متن کاملEnzymatic Hydrolysis of Olive Industry Solid Waste into Glucose, the Precursor of Bioethanol
Olive industry solid waste (OISW) is a by-product generated in the process of olive oil extraction. It is a lignocellulosic material consisting of cellulose, hemicelluloses, lignin and other extractives. In this work, a process for hydrolyzing the OISW into its monomers glucose, the precursor of bioethanol was developed. The hydrolysis process involves two stages: in the first stage, the O...
متن کامل